X-Irradiation of the Exteriorized or in Situ Intestine of the Rat

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Abstract
In situ or surgically exteriorized gastrointestinal tracts of rats were exposed to 250-kvp X-irradiation. Comparisons are made of the effects of these two modes of exposure with respect to mortality, hematologic injury, and histologic damage. Mortality studies on rats indicated that the LD50 was 1550 r and the mean survival time 7.1 days after irradiation of the exteriorized intestine. The LD50 for in situ exposure was 1620 r and mean survival time 5.7 days. A transient lymphophenia occurred after 900, 1500, and 1900 r which was maximal 5 days after exposure. It was more marked and persisted for a longer period after in situ exposure. The granulocyte count was also decreased in this group, reaching a minimum count at the same time. If the intestines were exteriorized during the radiation exposure, however, there was no decrease in the granulocyte count. Pathologic damage ranged from transitory mitotic inhibition after 900 r to severe focal mucosal ulceration after 1500 and 1900 r. Residual damage was evident as long as 43 days after irradiation.

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