Terpendoles, Novel ACAT Inhibitors Produced by Albophoma yamanashiensis. II. Structure Elucidation of Terpendoles A, B, C and D.
- 1 January 1995
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 48 (1) , 5-11
- https://doi.org/10.7164/antibiotics.48.5
Abstract
Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis.Keywords
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