Microenvironmental Factors Involved in the Establishment of Erythropoiesis in Bone Marrowa

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Abstract
Human erythropoiesis is focused near the venous sinuses of the bone marrow in EBI that are comprised of erythroblasts in intimate contact with supportive CM. The surface molecules and secreted products of fibroblastic reticular cells support the adhesion of erythroblasts and CM, and sequester growth factors near their surfaces. Cohesiveness within the EBI decreases as its associated erythroid cells mature, and the erythroblasts cease to express certain cytoadhesive molecules. Finally, the erythroblasts enucleate and separate from the EBI. Transiently motile reticulocytes enter the circulation through intracellular pores of venous sinus endothelial cells, and their nuclear remnants are ingested by CM or perisinal macrophages.