Fast, cheap and somewhat in control
Open Access
- 1 January 2006
- journal article
- review article
- Published by Springer Nature in Genome Biology
- Vol. 7 (8) , 114
- https://doi.org/10.1186/gb-2006-7-8-114
Abstract
Efforts to manipulate living organisms have raised the question of whether engineering principles of hierarchy, abstraction and design can be applied to biological systems. Here, we consider the practical challenges to controlling living organisms that must be surmounted, or at least managed, if synthetic biology and cellular bioengineering are to be productive.Keywords
This publication has 33 references indexed in Scilit:
- EXPANDING THE GENETIC CODEAnnual Review of Biophysics, 2006
- Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noiseNature, 2006
- Real-Time Kinetics of Gene Activity in Individual BacteriaCell, 2005
- Phenotypic Diversity, Population Growth, and Information in Fluctuating EnvironmentsScience, 2005
- Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic DiversityCell, 2005
- Diversity in times of adversity: probabilistic strategies in microbial survival gamesJournal of Theoretical Biology, 2005
- Control of Stochasticity in Eukaryotic Gene ExpressionScience, 2004
- Optimization of specificity in a cellular protein interaction network by negative selectionNature, 2003
- Metabolic load of recombinant protein production: Inhibition of cellular capacities for glucose uptake and respiration after induction of a heterologous gene in Escherichia coliBiotechnology & Bioengineering, 2003
- Error and attack tolerance of complex networksNature, 2000