Soluble Glomerular Basement Membrane Antigens in Normal Urine—Possible Autoimmunogens in Man

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Abstract
It has been known for some time that antiglomerular basement membrane (GBM) antibodies can cause glomerulonephritis in experimental animals but only recently has it been shown that they are pathogenetic in at least some instances of human glomerulonephritis (1-3). In this regard, the recent induction of glomerulonephritis in the monkey with human anti-GBM antibody eluted from human nephritic kidneys would appear to establish the pathogenicity of these antibodies in Goodpasture's syndrome and in some cases of rapidly advancing glomerulonephritis (3). Although the exact prevalence of antibodies directed against the glomerular basement membrane in cases of human glomerulonephritis is not known,