Release Rate of Indomethacin from Coated Granules
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 14 (5) , 683-687
- https://doi.org/10.3109/03639048809151893
Abstract
The purpose of this investigation was a study on sustained release coated granules manufactured by means of the air-suspension coating technique. The smoothed 12/20-mesh fractions of indomethacin granulation containing povidone as a binder were coated in a modified air-suspension coater with film of ethylcellulose-glyceryl monostea-rate mixture at various percents by weight of coat. The kinetics of drug release was determined and appears to conform to the first-order fashion. The relationship between the coating weight and the first-order release rate constant was developed and found to be in the form of exponential function.This publication has 5 references indexed in Scilit:
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