Whole Blood Chromium Level and Chromium Excretion in the Rat after Zinc Chromate Inhalation

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Abstract
Studies on absorption and excretion of Cr in rats exposed to known atmospheric concentrations of zinc chromate in an inhalation chamber and the influence of diurnal variations in physical activity were conducted. Cr analyses were performed on samples of blood, urine and feces using a method for determining Cr in small samples of biological material based on flameless atomic absorption spectrometry. Zinc chromate is absorbed quickly during exposure and excreted mainly via urine. An accumulation of Cr in blood was observed, followed by a slow elimination. Cr from zinc chromate probably enters the blood in the hexavalent state.