The Relation between Yolk Utilization and Differentiation in the Frog Embryo

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Abstract
The data reviewed suggest that the utilization of yolk platelets to form cytoplasmic proteins is associated with embryonic differentiation in the frog embryo. The mechanism of yolk utilization has been linked to the activity of the enzyme phosphoprotein phosphatase. The prior solubilization of yolk ribonucleoprotein in the chorda, as opposed to the presumptive neural ectoderm, suggests the speculation that the organizer area (chorda and somites) forms where the 1st and most active formation of cytoplasmic protein occurs. Isotopic and serological experiments seem to show a movement of nucleoproteins from the chorda mesoderm to the presumptive neural estoderm at the time of induction.