Facile synthesis of potent HIV-1 protease inhibitors containing a novel pseudo-symmetric dipeptide isostere

1 January 1993

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 13,p. 1052-1053
https://doi.org/10.1039/c39930001052

Abstract

A series of potent inhibitors of the HIV-1 protease containing a novel pseudo-symmetric dipeptide isostere 3 was synthesized via ring opening of a protected epoxide with various substituted hydrazines.

Keywords

POTENT HIV
PROTECTED EPOXIDE
VARIOUS SUBSTITUTED
FACILE SYNTHESIS
PROTEASE INHIBITORS
SUBSTITUTED HYDRAZINES
INHIBITORS CONTAINING
PROTEASE CONTAINING

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