The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors
Open Access
- 15 February 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 69 (3) , 677-687
- https://doi.org/10.1016/j.cardiores.2005.11.032
Abstract
At least 56 matrix metalloproteinase (MMP) inhibitors have been pursued as clinical candidates since the late 1970's when the first drug discovery prKeywords
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