ESTROGEN AND ALKALINE PHOSPHATASE ACTIVITY IN THE GENITAL TRACT OF THE MALE MOUSE1
- 1 January 1951
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 48 (1) , 25-33
- https://doi.org/10.1210/endo-48-1-25
Abstract
RECENTLY considerable attention has been focussed on the hormonej enzyme relationship by several groups of investigators using histochemical and cytochemical methods (Kochakian, 1950). The hormonal control of phosphatase activity in several areas of the male genital tract has been studied by the Gutmans (1938, 1939), Pazos and Huggins (1945), Huggins (1947), Atkinson (1948), Soulairac and Thibault (1948a, b), Dempsey (1948), Dempsey et al. (1949), Wislocki (1949), Stafford et al. (1949), and Nava and Fiore (1949). According to certain of these workers, castration of male mammals results in at least partial loss of phosphatase activity from the genital tract which can be restored by androgen replacement therapy. The present study was undertaken to determine the effects of estrogen on alkaline phosphatase activity in genital tissues of the male mouse, using a cytochemical technic. Seventy-nine male mice were used during the course of this investigation.Keywords
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