All‐ trans ‐retinoic acid (ATRA) responsive skin relapses of acute promyelocytic leukaemia followed by ATRA‐induced pseudotumour cerebri
- 1 March 1996
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 92 (4) , 937-940
- https://doi.org/10.1046/j.1365-2141.1996.411948.x
Abstract
A 30-year-old woman with acute promyelocytic leukaemia (APL) went into complete remission following idarubicin and cytarabine chemotherapy; 18 months later she developed repeated skin relapse, with no bone marrow involvement. DNA and RNA analysis of skin lesions revealed the presence of the PML/RAR alpha hybrid gene, which was not detected at the same time in bone marrow. The skin relapses were successfully treated by all-trans-retinoic acid (ATRA) as single agent over 2 years. However, prolonged administration of ATRA caused pseudotumour cerebri, which disappeared upon drug withdrawal. The absence of the hybrid gene in the bone marrow by RT-PCR analysis led to the patient being autografted.Keywords
This publication has 0 references indexed in Scilit: