Pigmented Nevi and Malignant Melanomas as Studied with a Specific Fluorescence Method
- 22 July 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 149 (3682) , 439-440
- https://doi.org/10.1126/science.149.3682.439
Abstract
A specific fluorescence is developed in melanocytes, nevus cells, and cells of malignant melanoma by treatment of the tissue with dry formaldehyde gas. The fluorescence is often stronger in melanocytes adjacent to nevi or melanomas than in normal melanocytes. The strongest fluorescence occurs in cells of malignant melanoma. Among the limited number of compounds that condense with formaldehyde to fluorescent derivatives, DOPA [β(3,4-dihydroxyphenyl)L-alanine] seems the most likely substance to give rise to the fluorescence observed in these lesions.This publication has 6 references indexed in Scilit:
- Fluoreszenzenzmethoden zur histochemischen Sichtbarmachung von Monoaminen. 2.. Identifizierung des fluoreszierenden Produktes aus Dopamin und FormaldehydHelvetica Chimica Acta, 1964
- Quantitative Determination of Dopa; Its Application to Measurement of Dopa in Urine and in the Assay of Tyrosinase in SerumJournal of Investigative Dermatology, 1964
- Observation on the adrenergic innervation of the skinCellular and Molecular Life Sciences, 1963
- Fluoreszenzmethoden zur histochemischen Sichtbarmachung von Monoaminen. 1. Identifizierung der fluoreszierenden Produkte aus Modellversuchen mit 6,7‐Dimethoxyisochinolinderivaten und FormaldehydHelvetica Chimica Acta, 1963
- FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDEJournal of Histochemistry & Cytochemistry, 1962
- Part III: General Considerations of Skin Pigmentation: The Melanocyte: Cytology and Cytochemistry11From the Division of Dermatology, University of Oregon Medical School, Portland, Oregon and the Department of Anatomy, Emory University Medical School, Atlanta, Georgia.Journal of Investigative Dermatology, 1959