A Cellular Anti-Apoptosis Protein is Cleaved by the HIV-1 Protease
- 1 January 1998
- book chapter
- Published by Springer Nature
- Vol. 436, 27-29
- https://doi.org/10.1007/978-1-4615-5373-1_3
Abstract
Cleavage of non-viral proteins is rarely observed with the HIV-1 protease (HIV pr). One such cleavage event occurs with bcl-2, an important cytoprotective protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppress HIV with non-cleavable mutants of bcl-2.Keywords
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