The effect of prolonged administration of carotene in the form of vegetables on the serum carotene and vitamin A levels in man

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Abstract
In 3 subjects a daily intake, in spinach and carrots, of the equivalent of 120,000 I.U./wk. raised the serum carotenoid content, expressed as [beta]-carotene, from about 100 to 160 [gamma]/100 cc, and the vit. A levels also. Consumption by 2 subjects of carrots, sufficient to supply twice the biological activity provided in the first 3 cases, produced a rapid rise in the serum carotene from 120 to 400 [gamma]/100 cc. within 3 wks. ; without significant change in the vit. A levels, which were around 143 and 155 i.u./100 cc. throughout. Pigmentation of the skin appeared and was intense at 3 and 4 wks.

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