INSULIN AND GLUCAGON DURING PENTOBARBITAL-ANESTHESIA

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 6  (2) , 91-95
Abstract
The induction of sodium pentobarbitone anesthesia (45 mg/kg i.p.) in 18 h fasted mice produced a mild transient hyperglycemia and a small but persistent increase in plasma glucagon concentrations. Plasma insulin concentrations became raised as the period of anesthesia progressed. Plasma glucagon concentrations remained elevated as consciousness was regained, and a 2nd episode of mild hyperglycemia was observed at this time. Plasma free fatty acid concentrations were not altered by the anesthesia and all parameters had returned to control values 4 h after consciousness was regained. During anesthesia glucose tolerance was impaired and the plasma insulin response to glucose and glucagon was enhanced. Higher plasma glucose and insulin concentrations were also observed after glucagon administration, and insulin hypoglycemia tests revealed a decrease in the rate of glucose disappearance during anesthesia. At 4 h after consciousness was regained all responses had returned to control values, except glucose tolerance which improved in comparison with controls. Impaired glucose homeostosis during pentobarbitone anesthesia apparently is dependent on changes in both the secretion and physiological effects of insulin and glucagon.

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