Massachusetts Medical Society

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Abstract
Severe Neurologic Reactions to Antiemetics†Many recent reports1 2 3 4 5 6 7 have pointed out a group of alarming neurologic side effects that occasionally accompany the use of the phenothiazine derivatives. These compounds include promazine (Sparine), mepazine (Pacatal), chlorpromazine (Thorazine), perphenazine (Trilafon) and prochlorperazine (Compazine) and have produced dramatic reactions in all age groups after administration of many dose ranges by several routes. Though more often seen after excessive doses, bizarre neurologic symptoms have been noted in many patients receiving only recommended amounts.4 , 5 , 7 Eight cases seen at the Children's Hospital in the past three months suggest that the occurrence of these reactions is not . . .

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