Highly Miniaturized Formats for In Vitro Drug Metabolism Assays Using Vivid® Fluorescent Substrates and Recombinant Human Cytochrome P450 Enzymes

This publication has 32 references indexed in Scilit:

• Early prediction of drug metabolism and toxicity: systems biology approach and modeling
  Drug Discovery Today, 2004
• Novel detection strategies for drug discovery
  Drug Discovery Today, 2002
• Improvement of “Hit-to-Lead” Optimization by Integration of in Vitro HTS Experimental Models for Early Determination of Pharmacokinetic Properties
  Combinatorial Chemistry & High Throughput Screening, 2002
• In vitro preclinical lead optimisation technologies (PLOTs) in pharmaceutical development
  Toxicology Letters, 2001
• Miniaturized HTS technologies – uHTS
  Drug Discovery Today, 2001
• In Vitro High Throughput Screening of Compounds for Favorable Metabolic Properties in Drug Discovery.
  Combinatorial Chemistry & High Throughput Screening, 2001
• High-Performance Liquid Chromatography Determination of N- and O-Demethylase Activities of Chemicals in Human Liver Microsomes: Application of Postcolumn Fluorescence Derivatization Using Nash Reagent
  Analytical Biochemistry, 2000
• Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential
  Xenobiotica, 1999
• Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes
  Journal of Clinical Pharmacy & Therapeutics, 1998
• Improved high-performance liquid chromatographic method for the determination of ethylmorphine and its metabolites in microsomal incubations and cell culture media
  Journal of Chromatography B: Biomedical Sciences and Applications, 1992