Quantitative Determination of Stanozolol and Its Metabolite in Urine by Gas Chromatography/Mass Spectrometry
- 1 March 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 14 (2) , 109-112
- https://doi.org/10.1093/jat/14.2.109
Abstract
The amount of stanozolol and 3′-hydroxystanozolol in urine was determined after oral administration of stanozolol. A gas chromatograph/mass selective detector equipped with a capillary column was used for these determinations. The GC/MS was operated in the SIM mode, and m/z 581, 669, and 315 were monitored for stanozolol, 3′-hydroxystanozolol, and calusterone (internal standard), respectively. The detection limit was approximately 1 ng/mL for both steroids. The maximum excretion rate of stanozolol was reached in 8 h and the maximum of 3′-hydroxystanozolol in 19 h. However, only 3% of the administered amount was recovered in urine.Keywords
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