Ipratropium Bromide

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Abstract
IPRATROPIUM bromide (8-isopropyl-noratropine-methobromide) is a synthetic quaternary ammonium congener of atropine. The first anticholinergic agent to be approved for use as a bronchodilator, it has recently been released for general use. I review here the background and the rationale for the use of an anticholinergic bronchodilator, and the pharmacology, clinical efficacy, and side effects of ipratropium bromide.BackgroundSince atropine and related anticholinergic alkaloids are widespread in the plant kingdom, their medicinal and recreational properties have been well known to many cultures for many centuries.1 Atropine, in the form of the leaves and root of Datura stramonium, was introduced . . .