Masking of the CBF1/RBPJ κ Transcriptional Repression Domain by Epstein-Barr Virus EBNA2
- 28 April 1995
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 268 (5210) , 560-563
- https://doi.org/10.1126/science.7725102
Abstract
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is a transcriptional activator that is essential for EBV-driven B cell immortalization. EBNA2 is targeted to responsive promoters through interaction with a cellular DNA binding protein, C promoter binding factor 1 (CBF1). A transcriptional repression domain has been identified within CBF1. This domain also interacts with EBNA2, and repression is masked by EBNA2 binding. Thus, EBNA2 acts by countering transcriptional repression. Mutation at amino acid 233 of CBF1 abolishes repression and correlates with a loss-of-function mutation in the Drosophila homolog Su(H).Keywords
This publication has 21 references indexed in Scilit:
- The suppressor of hairless protein participates in notch receptor signalingCell, 1994
- Mediation of Epstein-Barr Virus EBNA2 Transactivation by Recombination Signal-Binding Protein J κScience, 1994
- Repression versus activation in the control of gene transcriptionTrends in Biochemical Sciences, 1994
- DNA bending and orientation-dependent function of YY1 in the c-fos promoter.Genes & Development, 1993
- Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fatesCell, 1992
- The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system developmentCell, 1992
- Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A proteinPublished by Elsevier ,1991
- TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsPublished by Elsevier ,1991
- A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motifNature, 1989
- Genetic analysis of immortalizing functions of Epstein–Barr virus in human B lymphocytesNature, 1989