Familial Nature of Congenital Absence and Severe Dysgenesis of Both Kidneys

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Abstract
Seventy-one parents and 40 siblings of 41 index patients with bilateral renal agenesis, bilateral severe dysgenesis, or agenesis of one kidney and dysgenesis of the other were evaluated by gray-scale ultrasonography for genitourinary malformations. Nine per cent (10 of 111) had asymptomatic renal malformations, most often unilateral renal agenesis (4.5 per cent — a frequency that was significantly higher than the frequency of 0.3 per cent among 682 adults [P<0.004]).

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