METALLOPORPHYRIN STUDY IN EXPERIMENTAL CARCINOLOGY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 68  (1) , 40-48
Abstract
Antitumoral effects and intratumoral concentrations of a metalloporphyrin were studied in mice with solid chemo-induced or transplanted tumors. The synthesis of this molecule was realized with a stable metal (TPPS4SnCl2) (TPPS4InCl) and a radioactive metal (TPPS4113SnCl2) (TPPS4111InCl) [TPPS4 = tetraphenylporphine sulfonate]. The metal is introduced into the tetrapyrollic structure to give this molecule very high stability. The effect of the stable metalloporphyrin on tumoral kinetic parameters was analyzed. No tumoral regression was observed during the various experimental procedures. Even though radioactive molecules were found in the tumors, they were also present at high concentrations in the liver, spleen and kidneys more than 72 h after injection. Results are compared with those of various authors who used a molecule without metal, levels being measured by fluorescence in various organs and in the tumors. The interest of this metal molecule in cancer is discussed in relation to these new results.

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