Chlorpromazine produced response decrements as a function of problem difficulty level.

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Abstract
This is a study of the effects of acute administration of chlorpromazine hydrochloride on avoidance and escape behavior as a function of problem difficulty. 40 rats learned a simple avoidance, 40 others a discriminated avoidance. Each group was then subdivided, ½ being extinguished under drug, ½ with no drug. The drug was found to suppress acquisition and facilitate extinction of avoidances for both problems. Results further indicate that drug effects are some function of problem difficulty with a powerful interaction appearing between effects of drug administration during extinction and acquisition as problem difficulty increases. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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