Role of macrophage‐processed antigen in a Plasmodium berghei model

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Abstract
Malarial parasite could be processed by macrophages in vitro to release super antigens. These super antigens obtained from the peritoneal macrophages [from mice] were more protective than those processed by the splenic adherent cells. BCG-stimulated macrophages were also able to process the antigens efficiently and these antigens were even superior to those obtained from the unstimulated macrophages. These modified antigens were potent inducers of DFPS [delayed root-pad swelling] to malarial antigens. Apparently, parasite antigens, processed in vitro, carry specific immunogenic potential and are able to protect the recipients to parasite challenge.