Long-Term Intramuscular Prednisolone Therapy

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Abstract
Sixteen patients were treated with weekly intramuscular depot injections of prednisolone acetate for from 1 to 3 1/2 years (mean 2 1/2). Throughout this time they were closely observed to see whether any advantage would accrue from this avoidance of the oral route (i.e. the entry of the prednisolone via the alimentary tract and portal circulation). No advantage was demonstrated in respect of adaptation to therapy, tendency to weight gain, tendency to hypertension, pathological bruising, or liver amyloidosis. The observations did not exclude some benefit in respect of peptic ulceration, but it was concluded, as an impression, that the change from oral to intramuscular prednisolone therapy was of real value only at times of severe gastric or gastrointestinal disturbance.

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