Pergolide Presynaptically Inhibits Calcium‐Stimulated Release of γ‐Aminobutyric Acid
- 1 December 1991
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 57 (6) , 1927-1930
- https://doi.org/10.1111/j.1471-4159.1991.tb06405.x
Abstract
The release of γ‐aminobutyric acid (GABA) in rat dorsolateral striatum was studied using in vivo microdialysis. Dialysis was conducted 2 days after probe implantation in awake, freely moving rats using a modified Ringer solution. Calcium induced a reversible increase in GABA release that was abolished by tetrodotoxin but was only slightly attenuated by a maximally effective dose of pergolide, a D2 receptor agonist. It was thus concluded that pergolide inhibits calcium‐stimulated release of GABA presynaptically by a mechanism distinct from that of tetrodotoxin.Keywords
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