Effect of Normal Serum and Antithymocyte Serum on Friend Disease in Mice2

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Abstract
Silica, a specific macrophage toxin, and rabbit antimouse-thymocyte serum (ATS) which acts on thymus-dependent lymphocytes, were tested for their effect on Friend disease in mice. Both normal rabbit serum (NRS) and ATS increased the susceptibility of mice to infection with Friend disease virus (FDV), but the effect of NRS was less severe than that of ATS. Absorption of ATS with mouse erythrocytes decreased the potentiating effects, and further absorption with mouse immunoglobulin resulted in complete loss. Silica administered to mice given FDV intravenously did not change the course of the disease but, in mice given FDV intraperitoneally silica potentiated the infection.

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