ABSENCE OF COMMON ALL ANTIGEN ON NORMAL BIPOTENT MYELOID, ERYTHROID, AND GRANULOCYTE PROGENITORS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 58  (2) , 333-336
Abstract
The presence of the common acute lymphoblastic leukemia antigen (CALLA) on leukemic cells from the great majority of patients with non-T cell acute lymphoblastic leukemia and chronic myelogenous leukemia in blast crisis suggests that CALLA could be a differentiation antigen expressed by normal lymphoid and myeloid stem cells. Treatment with a murine monoclonal anti-CALLA antibody and complement lysed CALLA-positive leukemic cells quantitatively; similar treatment of nucleated cells from peripheral blood and bone marrow failed to affect the expression, in semisolid culture, of CFU[colony-forming unit]-G/E, BFU-E, CFU-E or CFU-C. CALLA apparently is not a normal differentiation antigen of the myeloid bipotent cell or its committed progenitors.