PANCREATIC ONCOFETAL ANTIGEN (POA) - ITS FREQUENCY AND LOCALIZATION IN HUMANS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 1  (1) , 37-48
Abstract
Pancreatic oncofetal antigen (POA) was isolated by affinity chromatography and used to standardize an immunoassay. POA was detected in fetal serum and in 97% of sera from 75 patients with carcinoma of the pancreas. Raised levels were also found in 16% of sera from 43 patients with chronic pancreatitis and in 3 of 156 patients with related conditions. Using an immunoperoxidase method, POA was regularly found in the fetal pancreas and in adult carcinoma of the pancreas. Weak staining was found in 1 carcinoma of the colon. Antisera from 2 other groups (Gelder and Moossa; Arndt and Thiele) react with the same antigenic moiety as does this anti-POA.

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