FATAL HYPERTHERMIA FOLLOWING HALOPERIDOL THERAPY OF SEDATIVE-HYPNOTIC WITHDRAWAL

  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (8) , 673-675
Abstract
A 30 yr old human male, with a history of methalqualone and barbiturate abuse, developed a delirium tremens-like syndrome following discontinuation of the medications. Shortly following high doses of parenteral haloperidol administered for treatment of the withdrawal syndrome, the patient developed severe hyperthermia, with body temperatures reaching as high as 108.degree. F. The hyperthermic episode was followed by cardiovascular collapse, multiple complications and death. Haloperidol therapy was casually related to the development of fatal hyperthermia. Thus the butyrophenone haloperidol, like the phenothiazine derivatives, can produce clinically important impairment of thermoregulation.

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