Preparation of Some Estriol Esters.
- 1 January 1963
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 11 (4) , 510-514
- https://doi.org/10.1248/cpb.11.510
Abstract
Estriol 16-monoacylates were obtained from estriol (I) by refluxing or warming estriol with carboxylic acids. A more drastic condition afforded estriol 16, 17-diacylates. Transesterification gave the same results. The reactions of estriol triacylates and estradiol diacylates with sodium borohydride gave estriol 16, 17-diacylates and estradiol 17-acylates, respectively. 3, 16α-Dihydroxyestra-1, 3, 5 (10)-trien-17-one diacetate (III) was transformed into estriol 16-acetate (IIa) by treatment with sodium borohydride. A milder condition afforded estriol 3, 16-diacetate (VI).Keywords
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