Piperazinylpyrazines with central serotoninmimetic activity
- 1 June 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (6) , 536-542
- https://doi.org/10.1021/jm00204a007
Abstract
A series of 2-(1-piperazinyl)pyrazines was synthesized and evaluated for central serotonin-like activity. The most interesting member of the series, 6-chloro-2-(1-piperazinyl)pyrazine (3a), had pharmacological properties characteristic of potent central serotoninmimetic activity and only weak peripheral serotoninmimetic action in rat uterus. Structural similarities between 3a and serotonin are discussed.This publication has 7 references indexed in Scilit:
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