Triploid fetus: An important consideration in the evaluation of very high maternal serum alpha-fetoprotein

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Abstract
Two patients referred for evaluation of very high maternal serum alpha‐fetoprotein (10–20 multiples of the median) were carrying triploid fetuses with placentas showing features of partial hydatidiform mole. The diagnosis of fetal triploidy should be considered when there is a very high maternal serum alpha‐fetoprotein and no ultrasound evidence of open neural tube defect, ventral wall defect, or any other explanation. Therefore, chromosomal analysis of amniotic fluid cells in such cases is essential.