PROCOAGULANT ACTIVITY OF SARCOMA SUBLINES WITH DIFFERENT METASTATIC POTENTIAL

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (4) , 733-735
Abstract
Cancer cell procoagulant activity influences metastasis formation by promoting fibrin deposition around tumors. The procoagulant activity of various tumor cell sublines with different metastatic capacity derived from metastatic nodules of a murine fibrosarcoma was studied. All the cells tested possessed a marked thromboplastin-like activity; they were heterogeneous as regards the degree of procoagulant activity; the 2 cell lines with virtually no metastatic capacity showed 6-8 times higher procoagulant activity than the cells from the parent line; in contrast, the procoagulant activity of the 2 sublines with higher metastatic capacity did not differ significantly from that of the parent line. Fibrin may be part of a defense reaction against cancer cell invasiveness.