Effects on Temperature of Morphine Injected into the Preoptic/Anterior Hypothalamus, Medulla Oblongata, and Peripherally in Unrestrained and Restrained Rats
- 1 December 1977
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 156 (3) , 523-526
- https://doi.org/10.3181/00379727-156-39971
Abstract
Summary Changes in Tre were determined in unrestrained rats after injections of morphine into the PO/AH and MED regions. Injections into the former site consistently caused hyperthermia, while medullary injections caused only inconsistent small responses. Destruction of the PO/AH region did not enhance the response to medullary injections of morphine. Restraint reversed responses to PO/AH and ip administration of morphine, resulting in hypothermia. These results provide additional evidence for the concept of a sensitive primary temperature control in the PO/AH region and a secondary control, which responds minimally to drugs, in the medulla.This publication has 0 references indexed in Scilit: