A Comparative Study of the Effect of Two Classes of Radiosensitizer on the Survival of Several E. coli B and K12 Mutants

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Abstract
The survival characteristics of 9 different mutants of Escherichia coli bacteria were studied under oxic and anoxic conditions and in the presence of a wide range of concentrations of a typical nitroxyl radiosensitizer (NPPN) [nor-pseudopelletierine-N-oxyl] and a typical electron affinic radiosensitizer (PNAP) [p-nitroacetophenone]. The data confirm that these 2 sensitizers operate by different and independent mechanisms in bacteria. Nitroxyl sensitization correlates with the anoxic sensitivity of the bacteria whereas the effect of the electron affinic sensitizer correlates with the OER [oxygen enhancement ratio] and oxic response of the bacteria. The 2 sensitizers are additive in their effects on the Rec A- mutant in contrast to O2/sensitizer combinations. PNAP can apparently only mimic 1 of the sensitizing effects of O2 and nitroxyl sensitization may be largely unrelated to O2 sensitization.

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