Pharmacokinetics of albendazole in man
- 1 January 1986
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 30 (6) , 705-708
- https://doi.org/10.1007/bf00608219
Abstract
The pharmacokinetics of albendazole were investigated in healthy volunteers and in patients receiving albendazole for treatment of hydatid disease. Unchanged albendazole was below detectable limits in plasma, urine, bile and cyst fluid. The major metabolite present in all fluids was the sulfoxide. Maximum concentrations of albendazole sulfoxide in plasma were very variable, probably due to variable absorption of albendazole.Keywords
This publication has 16 references indexed in Scilit:
- Treatment of cystic echinococcosis (Echinococcus granulosus) with mebendazole: Assessment of bound and free drug levels in cyst fluid and of parasite vitality in operative specimensEuropean Journal of Clinical Pharmacology, 1985
- The effect of dose form on the bioavailability of mebendazole in man.British Journal of Clinical Pharmacology, 1985
- Albendazole in hydatid disease.BMJ, 1983
- Polymorphic sulphoxidation of S-carboxymethyl-L-cysteine in manBiochemical Pharmacology, 1982
- Serum and cyst concentrations of mebendazole and flubendazole in hydatid disease.BMJ, 1982
- Bioavailability and tolerability of mebendazole in patients with inoperable hydatid diseaseTransactions of the Royal Society of Tropical Medicine and Hygiene, 1982
- Chemotherapy of alveolar echinococcosisEuropean Journal of Clinical Pharmacology, 1981
- Plasma concentrations of mebendazole during treatment of echinococcosisEuropean Journal of Clinical Pharmacology, 1980
- Analysis of Benzimidazoles in Body Fluids by High-Performance Liquid ChromatographyJournal of Pharmaceutical Sciences, 1980
- Thein vitro metabolism of mebendazole by pig, rat and dog liver fractionsEuropean Journal of Drug Metabolism and Pharmacokinetics, 1976