Prealbumin and Immunoglobulin in Serum and Cerebrospinal Fluid in Familial Amyloid Polyneuropathy

Abstract
Prealbumin, IgG, A and M concentrations in serum and CSF from patients with familial amyloid polyneuropathy (Japanese type) were determined and compared with those of asymptomatic relatives or controls. Prealbumin concentrations were not significantly different between them. Using polyacrylamide disc-gel electrophoresis, no qualitative difference in the serum prealbumin was found between them. Among the serum Ig, only the IgA concentration was significantly elevated in the patients as compared with asymptomatic relatives.