The effect of different types of physical exercise on glucose and citrulline synthesis in isolated rat liver parenchymal cells

Abstract
Rates of gluconeogenesis from lactate or pyruvate in hepatocytes from untrained rats were not increased by an acute (1 h) bout of exercise (running at 20 ). Hepatocytes from rats that had been exercise-trained for 1 month had lower rates of gluconeogenesis from lactate than cells from unexercised controls; the rates with pyruvate were identical. Hepatocytes from livers of trained animals immediately after 1 h of exercise synthesized glucose more rapidly and accumulated more citrulline than cells from resting rats.