Enantioselective synthesis of bicyclic compounds via catalytic 1,4-addition-ring closing metathesis
- 30 March 2001
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 8,p. 735-736
- https://doi.org/10.1039/b100283j
Abstract
A novel three step asymmetric annulation procedure comprises a tandem catalytic enantioselective 1,4-addition-allylic substitution, Grignard addition and ring closing metathesis (RCM) sequence to provide [6,6], [7,6], [8,6] and [6,7] bicyclic products with ee’s of 93–97% in which the size of both rings can easily be varied independent of each other.Keywords
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