Different Accessibility from the Artery and the Portal Vein of α- and β-Receptors Involved in the Sympathetic Nerve Action on Glycogenolysis and Hemodynamics in Perfused Rat Liver

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Abstract
In perfused rat liver perivascular nerve stimulation (7.5 Hz, 20 V, 2 ms, 5 min) at the liver hilus caused an increase in glucose and lactate output and a decrease in flow. The influence of the .alpha.1-receptor blocker prazosine and the .beta.-blocker propranolol on these nerve effects was studied in the isolated rat liver perfused classically via the portal vein only and, as developed recently, via both the hepatic artery and the portal vein. These results allow the following conclusions: A subpopulation of .beta.-receptors can play a permissive role in the .alpha.1-receptor-mediated sympathetic nerve action on glucose and lactate metabolism. These .beta.-receptors in contrast to .alpha.1-receptors were only accessible in livers perfused simultaneously via the hepatic artery and the portal vein.