Renal Extraction of PAH in Man Following Abdominal Aortography

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Abstract
BECAUSE angiographic contrast agents are excreted by the kidney almost exclusively, their effect upon renal function has been a subject of continuing interest. While early reports dealt with gross organ response, more systematic attempts have been made in the past fifteen years to define the precise nature of the interaction between contrast media and the kidney in both histologic and physiologic terms, in animal as well as in man. Experiments in man relating the response of the kidney to contrast agents have been based, for the most part, on indirect and gross measurements of renal function, or have employed contrast agents no longer used because of their high level of toxicity (1, 4, 5, 8, 9). It seemed reasonable to investigate the response of the human kidney to diagnostic doses of currently used contrast agents by measuring a precise and relevant renal function, the renal extraction of paraaminohippuric acid (PAH). Material and Methods Patients undergoing abdominal aortography, principally for evalua...

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