Biophysical model of synaptic plasticity dynamics
- 1 September 2003
- journal article
- research article
- Published by Springer Nature in Biological Cybernetics
- Vol. 89 (3) , 214-226
- https://doi.org/10.1007/s00422-003-0422-x
Abstract
We discuss a biophysical model of synaptic plasticity that provides a unified view of the outcomes of synaptic modification protocols, including: (1) prescribed time courses of postsynaptic intracellular Ca2+ release, (2) postsynaptic voltage clamping with presentation of presynaptic spike trains at various frequencies, (3) direct postsynaptic response to presynaptic spike trains at various frequencies, and (4) LTP/LTD as a response to precisely timed presynaptic and postsynaptic spikes.Keywords
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