Cloned fragments of the plasmid ColV,I-K94 specifying virulence and serum resistance
- 1 June 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 279 (5716) , 778-781
- https://doi.org/10.1038/279778a0
Abstract
A cloned BamH1-generated fragment of ColV,I-K94 increased the virulence of Escherichia coli, causing an approximately 100-fold reduction in LD50 for chicks. A genetic determinant for resistance to the bactericidal effects of serum was mapped to a 5300 base-pair sequence within the fragment. Neither colicin V nor immunity to colicin V affected the pathogenicity of E. coli for chicks.Keywords
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