Rapid localization of membrane skeletal protein 4.1 (EL1) to human chromosome 1p33→p34.2 by nonradioactive in situ hybridization

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Abstract
Hereditary elliptocytosis (HE) is a heterogeneous group of red-cell disorders. One class of HE patients was shown to have a mutated erythrocyte membrane skeletal protein 4.1 gene. We have recently shown that human protein 4.1 contains multiple isoforms with novel sizes, functions, and tissue-specific expression. Here, we report the subregional localization of this gene to human chromosome 1p33→p34.2, based on the fractional length, by nonradioactive in situ hybridization.

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