Distribution of some disulfhydryl-containing chelating agents labeled with indium-113m and gallium-67 in mice.

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Abstract
The organ distribution of new disulfhydryl-compounds, 2,3-dimercaptopropionylglycine (DMPG) and 2-mercaptopropionyl-L-cysteine (MPC), labeled with 113mIn(III) and 67Ga(III) were examined in mice, and the results were compared with those of dimercaptosuccinic acid complex and metal ion without those ligands to evaluate their applicabilities as diagnostic agent in nuclear medicine. The DMPG complex was found to be localized in liver, whereas the MPC complex in kidney. The addition of metal ion carrier varies the distribution patterns of the complex species, on account of the formation of the polymerized products. In the case of In complexes, the behavior of the ligand was reflected to their distribution patterns more clearly than in the case of Ga complexes. The complex species formed in the labeling reactions were characterized by the electrophoretic and gel-filtration techniques.

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