Enhancement of Immune Function and Tumor Growth Inhibition by Antibodies Against Prostaglandin E2
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 12 (1) , 11-23
- https://doi.org/10.3109/08820138309060853
Abstract
Mice bearing a Lewis lung carcinoma (LLC) were passively immunized against prostaglandin E2 (PGE2 by administration of rabbit serum containing anti-PGE2 antibodies. The effect of PGE2-inxnune serum on the suppressed imnunity of LLC-bearing mice was examined. Treatment of tumor-bearing mice with anti-PGE2 prevented the suppression of lymphocyte mito-genesis and the alterations in macrophage migration which typically occur in LLC-bearing mice. Furthermore, tumor growth was reduced In LLC-bearing mice which received antibodies directed against PGE2 rather than a placebo treatment.This publication has 11 references indexed in Scilit:
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