Megakaryocyte Polyploidization in May-Hegglin Anomaly
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 60 (1) , 45-52
- https://doi.org/10.1159/000207694
Abstract
Polyploidization of megakaryocytes was studied in bone marrow aspirates from 3 patients with May-Hegglin anomaly by combined application of cytophotometric determination of the DNA content and autoradiography with 3H-TdR labeling in vitro. A marked elevation of the influx of progenitor cells into the megakaryocytic cell system as well as a decreased maturation capacity from type II to type III megakaryocytes was observed possibly contributing to the pathological platelet sequestration. The polyploidization activity as assessed by 3H-TdR labeling and nuclear DNA content was normal.Keywords
This publication has 2 references indexed in Scilit:
- Ultrastructural Studies of the May-Hegglin AnomalyBlood, 1965
- Kinetics of Megacaryocyte Proliferation.Experimental Biology and Medicine, 1962