Immunologic Studies of the Rabbit Coagulating Gland and Its Secretions12

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Abstract
Evaluation of hetero- and isoimmune sera to rabbit “coagulo-prostatic fluid” (CPF—a normal secretory product of the coagulating and prostate glands of the male rabbit) by the methods of gel diffusion precipitation and passive hemagglutination showed that a portion of the antibodies developed in these sera were tissue and species specific. The specificity of antibodies to CPF were further shown by gel diffusion precipitation to be of a specificity identical to autoantibodies developed in consequence of multiple in situ freezing (cryostimulation) of the rabbit coagulating gland. The findings of the present study appear to extend and confirm previous immunohistologic studies suggesting that the autoimmune response after cryostimulation occurred in consequence of the liberation of a naturally sequestered antigen (i.e., CPF, to which tolerance was not previously developed) into the circulation.

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